IOCMs were classified into four subgroups: a) monoclonal IgM, b) polyclonal IgM, c) isotype-unrelated IgM, and d) monoclonal IgM/IgM+IgG (IgA) aggregates. In patients with no remission (NR) at 4 weeks of therapy, IOCM analysis was performed. None of the patients had undergone renal biopsy prior to the start of treatment with mycophenolate mofetil and CNI. We prospectively analysed serum and urine samples obtained from patients with anti-GBM nephritis treated with calcineurin inhibitors and mycophenolate mofetil. We aimed to evaluate the potential of IOCM analysis in patients with anti-GBM nephritis on treatment with mycophenolate mofetil and calcineurin inhibitors (CNI). Isolated oligoclonal IgM-B cells (IOCMs) in polyclonal serum can, however, be used as a surrogate. However, serum-free light chains (sFLCs) are often unavailable. Guidelines recommend the assessment of serum-free light chains (sFLC) for monitoring of the response to immunosuppressant therapy in anti-glomerular basement membrane antibody (anti-GBM) nephritis. This version will be available for download until November 15th, if you wish to download this game now, choose from available downlaod links below.Successful AMR-positive isolated oligoclonal IgM-B cells in anti-GBM nephritis: A single-centre experience. The game is a 5 vs 5 cooperative shooter, in which players will work together to complete a series of objectives.
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